Polymeric Nanocapsules Containing an Antiseptic Agent Obtained by Controlled Nanoprecipitation onto Water‐in‐Oil Miniemulsion Droplets

Abstract

The modified nanoprecipitation of polymers onto stable nanodroplets has been successfully applied to prepare well-defined nanocapsules whose core is composing of an antiseptic agent, i.e., chlorhexidine digluconate aqueous solution. The stable nanodroplets were obtained by inverse miniemulsions with an aqueous antiseptic solution dispersed in an organic medium of solvent/nonsolvent mixture containing an oil-soluble surfactant and the polymer for the shell formation. The change of gradient of the solvent/nonsolvent mixture of dichloromethane/cyclohexane, obtained by heating at 50 degrees C, led to the precipitation of the polymer in the organic continuous phase and deposition onto the large interface of the aqueous miniemulsion droplets. The monodisperse polymer nanocapsules with the size range of 240-80 nm were achieved as a function of the amount of surfactant. Using various polymer contents, molecular weights and types, an encapsulation efficiency of 20-100% was obtained as detected by proton-nuclear magnetic resonance spectroscopy ((1)H NMR) measurements. The nanocapsules could be easily transferred into water as continuous phase resulting in aqueous dispersions with nanocapsules containing an aqueous core with the antiseptic agent. The encapsulated amount of the antiseptic agent was evaluated to indicate the durability of the nanocapsule's wall. In addition, the use of different types of polymers having glass transition temperatures (T(g)) ranging from 10 to 100 degrees C in this process has been also successful.