Abstract
Polymer-based nanocapsules have been widely studied as a potential drug delivery system in recent years. Nanocapsules—as one of kind nanoparticle—provide a unique nanostructure, consisting of a liquid/solid core with a polymeric shell. This is of increasing interest in drug delivery applications. In this review, nanocapsules delivery systems studied in last decade are reviewed, along with nanocapsule formulation, characterizations of physical/chemical/biologic properties and applications. Furthermore, the challenges and opportunities of nanocapsules applications are also proposed.
Highlights
Over the past century, nanotechnology has increasingly acquired a crucial role in drug delivery [1,2], diagnostic [3,4], biomedical imaging [5,6] and other medicine-related domains [7,8,9]
A polymeric nanocapsule consists of a liquid/solid core coated with a polymeric shell, which is absent in the nanosphere [17]
The permeability of nanocapsules were modulated by a stimuli-responsive, multilayered polymeric shell made of four polyelectrolytes, including Eudragit® L100, chitosan, sodium alginate, and poly-L-arginine, thereby presenting a delayed release in the acidic pH environment of the gastrointestinal tract, while a fast release at the pH found in the intestines
Summary
Nanotechnology has increasingly acquired a crucial role in drug delivery [1,2], diagnostic [3,4], biomedical imaging [5,6] and other medicine-related domains [7,8,9]. Polymeric nanoparticles can modulate the pharmacokinetic properties of various active substances due to the subcellular size of nanoparticles, and affect biocompatibility and/or biodegradability of polymers employed to produce the nanoparticles. Depending on their internal structure, polymeric nanoparticles may be further classified as nanospheres or nanocapsules [16]. Polymeric nanocapsules have attracted more interest in drug delivery applications, benefitting from their core-shell microstructure. The solid/oil core of nanocapsules can effectively increase drug-loading efficiency, while reduce the polymeric matrix content of nanoparticles [18]. The challenges and opportunities of nanocapsules applications will be heighted and discussed
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