Abstract
For early-stage breast cancers mastectomy is an aggressive form of treatment. Therefore, there is a need for new treatment strategies that can enhance the use of lumpectomy by eliminating residual cancer cells with limited side effects to reduce local recurrence. Although, various radiotherapy-based methods have been developed, residual cells are found in 20–55% of the time at the first operation. Furthermore, some current treatment methods result in poor cosmesis. For the last decade, the authors have been exploring the use of polymeric composite materials in single and multi-modal implantable biomedical devices for post-operative treatment of breast cancer. In this paper, the concept and working principles of the devices, as well as selected results from experimental and numerical investigations, are presented. The results show the potential of the biomedical implants for cancer treatment.
Highlights
Breast cancer is the most frequently occuring cancer among females in the world. [1] It accounted for 512, 900 deaths worldwide out of 1.7 million new cases in 2012 (15% of all cancer deaths among females and 25% of all cancer cases). [1] Advances in detection techniques have led to the implementation of screening programmes, resulting in increased detection of early breast carcinomas. [2] For such small breast cancers, mastectomy is an aggressive form of treatment
The authors have explored the use of polymeric composite materials in the development of implantable biomedical device (IBD) for the post-operative single mode and multi-modal treatment of breast cancer. [12,13,14,15,16,17,18,19,20]
Results of in-vitro hyperthermia studies obtained from this device, [14] showed that the device was able to kill or reduce the viability of breast cancer cells in the vicinity of the elevated temperature fields that surround it
Summary
Breast cancer is the most frequently occuring cancer among females in the world. [1] It accounted for 512, 900 deaths worldwide out of 1.7 million new cases in 2012 (15% of all cancer deaths among females and 25% of all cancer cases). [1] Advances in detection techniques have led to the implementation of screening programmes, resulting in increased detection of early breast carcinomas. [2] For such small breast cancers, mastectomy is an aggressive form of treatment. Various localized radiotherapy based methods and techniques such as intraoperative radiotherapy and partial breast irradiation have been developed over the last decade, [4]. Nanocomposites for breast cancer treatment available data suggests that an increase in local recurrence rates is possible. The clinical use of heat (thermotherapy) for the treatment of cancer has received significant attention due to its minimal side effects, flexible treatment regime and potential to enhance the therapeutic efficacy of conventional cancer therapies. The authors have explored the use of polymeric composite materials in the development of implantable biomedical device (IBD) for the post-operative single mode and multi-modal treatment of breast cancer.
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