Abstract
This paper focuses on the significant properties of hydrogels prepared with polymeric biomaterials: solely biopolymers (gelatin (G) and sodium alginate (SA) as base polymer) or in combination with synthetic and bio polymers (polyvinylpyrrolidone (PVP) and carboxymethylcellulose (CMC)) for biomedical application. Four kinds of hydrogels: G/SA, G/SA/SB (without and with seabuckthron oil (SB)) and PVP/CMC, PVP/CMC/BA (without and with boric acid (BA)) which are different from each other concerning shape, size, color, texture and properties point of view were achieved. G/SA and G/SA/SB hydrogels vary from pale yellow to orange and a little rubber like having 42-48 % moisture. On the other hand, PVP/CMC and PVP/CMC/BA hydrogels are transparent and soft gel like containing about 90-95% moisture. Both G/SA and PVP/CMC hydrogels show similar trend of viscoelastic behaviour within whole range of measured angular frequency (0.1 – 100 rad.s-1). However, the presence of BA in PVP/CMC/BA, increases the storage modulus, loss modulus and complex viscosity of hydrogel, and the presence of SB in G/SA/SB demonstrates the decrease all of these values. G/SA based hydrogel possesses natural antimicrobial property whereas PVP/CMC based hydrogel needs to incorporate antimicrobial agent to comprise antimicrobial property within the hydrogel. G/SA hydrogels show water absorption capacity until 90 min whereas PVP/CMC hydrogels are able to absorb water steadily till 240 min. Finally, it can be mentioned that all four hydrogels: G/SA, G/SA/SB, PVP/CMC, PVP/CMC/BA which meet the basic requirements of hydrogel dressings, could be recommended as dressing materials for healing of burn or cut wound as well as a tool for transdermal drug delivery.
Highlights
A biomaterial is a synthetic material used to replace part of a living system or to function in intimate contact with living tissue [1]
This paper focuses on the significant properties of hydrogels prepared with polymeric biomaterials: solely biopolymers (gelatin (G) and sodium alginate (SA) as base polymer) or in combination with synthetic and bio polymers (polyvinylpyrrolidone (PVP) and carboxymethylcellulose (CMC)) for biomedical application
All four kinds of hydrogels (G/SA & G/SA/seabuckthorn oil (SB) and PVP/CMC & PVP/CMC/boric acid (BA)) meet the basic requirements of existing dressing materials usually used for health care
Summary
A biomaterial is a synthetic material used to replace part of a living system or to function in intimate contact with living tissue [1]. Medical applications of polymers fall into three broad categories: (i) extracorporeal uses (catheters, tubing, and fluid lines; dialysis membranes/artificial kidney; ocular devices; wound dressings and artificial skin), (ii) permanently implanted devices (sensory devices; cardiovascular devices; orthopedic devices; dental devices), and (iii) temporary implants (degradable sutures; implantable drug delivery systems; polymeric scaffolds for cell or tissue transplants; temporary vascular grafts and arterial stents ; temporary small bone fixation devices, transdermal drug delivery) [5,6] Among all these prospective applications of PB in biomedical applications, concentration has given for the development of polymeric hydrogels as wound dressing cum wound healing material considering its application for extracorporeal purposes. The properties of two types of hydrogels (the one is prepared solely with biopolymers and the other is prepared in combination with biopolymer and synthetic polymer) were compared and mentioned in this paper
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