Abstract
Polymer/silica hybrid hollow nanoparticles (PSHNs) with channels and thermo-responsive gatekeepers for drug storage and on-off release were successfully synthesized using core-shell polymeric micelles of poly(N-isopropylacrylamide)-b-poly(4-vinylpyridine) (PNIPAM-b-P4VP) as a template. The core cavity was easily obtained using a thermo-responsive PNIPAM polymer without the application of calcination techniques. PSHNs featuring channels and thermo-responsive gatekeepers formed due to the swollen and soluble PNIPAM segment. The void volume and thickness shell of the PSHNs could be tuned by adjusting the pH value and temperature of the solution, as well as the mean polymeric micelle diameter and the molar ratio of TMOS to P4VP. Doxorubicin (DOX) was used as a model drug loaded into the PSHNs. A high drug loading content was achieved due to the hollow core and large surface area of the PSHNs.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
