Abstract
The utilization of polymer/metal organic framework (MOF) nanocomposites in various biomedical applications has been widely studied due to their unique properties that arise from MOFs or hybrid composite systems. This review focuses on the types of polymer/MOF nanocomposites used in drug delivery and imaging applications. Initially, a comprehensive introduction to the synthesis and structure of MOFs and bio-MOFs is presented. Subsequently, the properties and the performance of polymer/MOF nanocomposites used in these applications are examined, in relation to the approach applied for their synthesis: (i) non-covalent attachment, (ii) covalent attachment, (iii) polymer coordination to metal ions, (iv) MOF encapsulation in polymers, and (v) other strategies. A critical comparison and discussion of the effectiveness of polymer/MOF nanocomposites regarding their synthesis methods and their structural characteristics is presented.
Highlights
The homogeneous dispersion of inorganic, organic, or hybrid nanoscale components inside a polymeric matrix results in materials with physically and/or chemically distinct phases that are called polymer nanocomposites
MOFs can have their surface further modified, thereby increasing their functionality. These characteristics make MOFs ideal candidates for biomedical applications like drug delivery and magnetic resonance imaging (MRI) [17,18,19]. As it concerns drug delivery, the high surface areas and large pore sizes of MOFs are favorable for the encapsulation of high drug loadings [20], while the high structural and functional flexibility of MOFs allow their adaption to the shape, size, and functionality of the drug molecules [20,21]
We examine the various types of polymer/MOF nanocomposites used in biomedical applications, and in drug delivery and imaging
Summary
The homogeneous dispersion of inorganic, organic, or hybrid nanoscale components inside a polymeric matrix results in materials with physically and/or chemically distinct phases that are called polymer nanocomposites. As part of more complex systems for biomedical applications, nanostructured materials may exhibit various functions They can reinforce the polymer matrix or offer some new property, they can interact. MOFs can have their surface further modified, thereby increasing their functionality These characteristics make MOFs ideal candidates for biomedical applications like drug delivery and magnetic resonance imaging (MRI) [17,18,19]. As it concerns drug delivery, the high surface areas and large pore sizes of MOFs are favorable for the encapsulation of high drug loadings [20], while the high structural and functional flexibility of MOFs allow their adaption to the shape, size, and functionality of the drug molecules [20,21]. We focused on the different approaches followed to produce the composites and discuss the findings regarding the behavior of the composites in each application
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