Abstract
Aim:To study the efficiency of multifunctional polymer-based superparamagnetic iron oxide nanoparticles (bioferrofluids) as a T2 magnetic resonance contrast agent and their uptake and toxicity in liver.Materials & methods:Mice were intravenously injected with bioferrofluids and Endorem®. The magnetic resonance efficiency, uptake and in vivo toxicity were investigated by means of magnetic resonance imaging (MRI) and histological techniques.Results:Bioferrofluids are a good T2 contrast agent with a higher r2/r1 ratio than Endorem. Bioferrofluids have a shorter blood circulation time and persist in liver for longer time period compared with Endorem. Both bioferrofluids and Endorem do not generate any noticeable histological lesions in liver over a period of 60 days post-injection.Conclusion:Our bioferrofluids are powerful diagnostic tool without any observed toxicity over a period of 60 days post-injection.
Highlights
Over the past few decades biological applications of nanomaterials have become a subject of intense research activity [1]
We explored the diagnostic potential of these nanoparticles as an magnetic resonance imaging (MRI) contrast agent and their uptake in liver, without neglecting their toxicological effects
transmission electron microscopy (TEM) images show that the polymer coating did not give an appreciable contrast against the carbon film of the sample holder; only the maghemite magnetic nanoparticles (MNPs) were visible
Summary
Over the past few decades biological applications of nanomaterials have become a subject of intense research activity [1]. Particles of about 20 nm or less have unique properties that adjust very well to functionalities of interest in biomedical applications Besides their size being comparable to many biological objects, their magnetic behavior is superparamagnetic, so they can be magnetized in the presence of an external magnetic field, their magnetization coming to zero as soon as the field is suppressed [3]. Their magnetization values are orders of higher magnitude compared with the values corresponding to transition metal or lanthanide ions, so they can strongly affect the spin–spin relaxation times (T2) of nearby water protons. Their strong magnetization allows them to be fixed, moved, tagged or detected magnetically making them useful in bioseparation, diagnosis or in targeted
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