Abstract
Background Surface modifications of silicone have been attempted to reduce the incidence of shunt infections. However, the influence of surface hydrophobicity, roughness, and functional groups on bacterial adhesion has not been fully elucidated, and reports of protein effects are conflicting. Therefore, we have tested silicone coated with different biopolymers, silanes, and proteins to determine how these modifications influence Staphylococcus epidermidis adhesion and colonization.
Highlights
Surface modifications of silicone have been attempted to reduce the incidence of shunt infections
The contact angles of FAS, OTS, heparin, and hyaluronan coating on silicone were 112.2°, 102.3°, 55.3°, and 55.3°, respectively, and these coatings were stable for 30 days
All protein immobilized on OTS/silicone surfaces significantly reduced bacterial adhesion by around 75% compared to untreated silicone, while physically adsorbed bovine serum albumin (BSA) on silicone reduced adhesion by only 30%
Summary
Polymer and protein surface coatings on silicone: effect on Staphylococcus epidermidis adhesion and colonization. KY Simon Ng*1, Haiying Tang, Ting Cao, Anfeng Wang, Xuemei Liang, Steven O Salley and James P McAllister II2. Address: 1Department of Chemical Engineering and Materials Science, Wayne State University, 5050 Anthony Wayne Drive, Detroit, MI 48202 USA and 2Department of Pediatric Neurosurgery, Children's Hospital of Michigan and Wayne State University, 4201 Antoine Street, UHC-6E, Detroit, MI 48201, USA. 50th Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida Meeting abstracts – A single PDF containing all abstracts in this supplement is available here.
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