Abstract
A drug delivery system based on ɛ-polylysine-modified titania nanotube (ɛ-PL-TNTs) arrays was prepared. Polylysine on the nanotubes’ surface can effectively bind with alendronate, a drug for the treatment of osteoporosis, through chemical bond. The bonds are fairly stable in an acid environment and cannot easily break up in a physiological environment. The ɛ-PL-TNTs increased the amount of drug loading by 9% in weight. The in vitro release profile of alendronate from ɛ-PL-TNTs showed a significant reduced burst release and an extended overall release of more than 15 days.
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