Polyketides with quorum sensing inhibitory activity from the marine-derived fungus Aspergillus sp. ZF-79

Abstract

Seven compounds were isolated from a marine-derived fungus Aspergillus sp. ZF-79, including three new polyketides (1–3), named asperochrins D-F, along with four known compounds 4–7. Their structures were determined on the basis of spectroscopic methods. All the compounds were tested for quorum sensing inhibitory (QSI) activity. Compounds 1, 3, 4, 5, and 6 exhibited QSI activity against Chromobacterium violaceum CV026 with MIC values of 50, 100, 50, 50, and 6.25 μM, respectively.