Polyketides with anti-inflammatory activity isolated from Rhodiola tibetica endophytic fungus Penicillium sp. HJT-A-10

Abstract

Seven undescribed polyketide compounds (1–4, 9–11) and six known polyketide compounds (5–8,12, 13) were isolated from Rhodiola tibetica endophytic Penicillium sp. HJT-A-10. The structural of seven undescribed polyketides metabolites were established on the basis of spectroscopic methods. The results of anti-inflammatory activity showed that compounds 1–8，10–13 had significant inhibitory effects on LPS-induced NO production in RAW 264.7 cells.