Abstract
In our continuous chemical investigation on the marine-derived fungus Dichotomomyces cejpii F31-1, two new polyketides dichocetides B-C (1, 2), two new alkaloids dichotomocejs E-F (3, 4), and three known fumiquinozalines: scequinadoline A (5), quinadoline A (6), and scequinadoline E (7) were discovered from the culture broth and the mycelium in the culture medium, by the addition of l-tryptophan and l-phenylalanine. Their chemical structures were established by one dimensional (1D), two dimensional (2D) nuclear magnetic resonance (NMR) and high resolution mass spectrometry (HR-MS) data. Among them, scequinadoline A (5) exhibited significant inhibitory activity against dengue virus serotype 2 production by standard plaque assay, equivalent to the positive control andrographlide. Scequinadoline A (5) possesses the potential for further development as a dengue virus inhibitor.
Highlights
Dengue, the most prevalent mosquito-borne infection, is induced by four genetically similar, antigenically distinct serotypes of dengue virus (DENV)—DENV 1–4 [1,2]
The percentage of DENV 2 infection was optimized by varying the multiplicity of infection
HEK293T/17 cells were infected with DENV 2 at multiplicity of infections (MOI) of 0.1, 0.5, 1, 5, 10 for
Summary
The most prevalent mosquito-borne infection, is induced by four genetically similar, antigenically distinct serotypes of dengue virus (DENV)—DENV 1–4 [1,2]. The discovery and development of safe and effective antiviral drugs have become imperative [3]. Among the compounds isolated from marine organisms, small metabolites of isolatedorigin from marine organisms, small metabolites of fungal origin represent a very important source fungal represent a very important source for drug discovery [7,8]. Through the addition of amino acids, twenty-eight diverse compounds were obtained from crassum. Through the addition of amino acids, twenty-eight diverse compounds were the culture broth. Whenbroth searching for dengue virusfor inhibitors, a methanol extract of the mycelium obtained from the[9]. When searching dengue virus inhibitors, a methanol extract displayed inhibitory activityinhibitory against DENV. An additional two new polyketides dichocetides standard plaque assay, equivalent to the positive control andrographlide [10].
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