Abstract
This paper presents the results of the first part of testing a novel electrospun fiber mat based on a unique macromolecule: polyisobutylene (PIB). A PIB-based compound containing zinc oxide (ZnO) was electrospun into self-supporting mats of 203.75 and 295.5 g/m2 that were investigated using a variety of techniques. The results show that the hydrophobic mats are not cytotoxic, resist fibroblast cell adhesion and biofilm formation and are comfortable and easy to breathe through for use as a mask. The mats show great promise for personal protective equipment and other applications.
Highlights
Polyisobutylene (PIB) is a unique elastomeric macromolecule, with exceptional impermeability to gases and moisture, high damping and excellent chemical and oxidative stability [1]
Due to the unique low permeability of linear poly(styrene-b-isobutylene-b-styrene) triblock copolymer (L_SIBS), sustained drug delivery is achieved, but only approximately 10% of the encapsulated drug, Taxol, is eluted from the coating, which is therapeutic for this application
For biomedical applications requiring more release, it was theorized that encapsulating drugs into electrospun fiber mats would provide burst release but exhibited slow continuous release over time (20–40% release in 28 days)
Summary
Polyisobutylene (PIB) is a unique elastomeric macromolecule, with exceptional impermeability to gases and moisture, high damping and excellent chemical and oxidative stability [1]. ElectroNanosprayTM, a technology of generating high-velocity spray of nanoparticles, was used to coat several batches of Arbomatrix© polymers loaded with dexamethasone (DXM), a model drug, onto coronary stents This particulate coating did not have an initial burst release but exhibited slow continuous release over time (20–40% release in 28 days) [14]. For biomedical applications requiring more release, it was theorized that encapsulating drugs into electrospun fiber mats would provide burst release but exhibited slow continuous release over time (20–40% release in 28 days). For biomedical applications requiring more release, it was theorized that encapsulating drugs into electrospun fiber mats would provide a high asuhrifgahcesuarrefaacteoavreoalutmo evorlautimo etorarteioleatoseremleoarsee dmruorge. Molecules 2021, 26, 5207 butyl rubber, with zinc oxide (ZnO) as reinforcing filler This new compound was 3suofc cessfully electrospun into self-supporting fiber mats. Based on thes5e.23results, the investCigated ZnO-containin2g85electrosppuunn mattss do no9t3i.n38hibit growth of norm93a.0l 0ffiibroblasts but sloSwi down their prolife10ra2tion
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