Abstract
The first total synthesis for the (+)-hyacinthacine A 3 1 in a highly stereocontrolled manner, is reported herein. An appropriately protected polyhydroxylated pyrrolidine, such as (2 R,3 R,4 R,5 R)-3,4-dibenzyloxy- N- tert-butyloxycarbonyl-2′- O- tert-butyldiphenylsilyl-2,5-bis(hydroxymethyl)pyrrolidine 2, (DMDP protected), readily available from d-fructose, was chosen as the homochiral starting material. The absolute configuration of natural 1 is also unambiguously established.
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