Abstract
Hydroxylated 4-thiaflavans, possessing the antioxidant features of catechol containing flavonoids and/or tocopherols, were evaluated as protective agents against oxidation damage induced in herring sperm DNA by cumene hydroperoxide (CumOOH) or by the glutathione/ferric ion (GSH/Fe 3+) system. Our data indicate that the effective protection exerted by some of the tested compounds is overall higher than those provided by catechin and α-tocopherol, which might be attributed both to the scavenging properties and chelation of Fe 2+ ions.
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