Polyhydroxyalkanoates

Abstract

Human dependence on number of chemicals or chemical derivatives has increased alarmingly. Among the commodity chemicals, plastics are becoming independent for our modern lifestyle, as the usage of plastics is increasing worryingly. However, these synthetic plastics are extremely persistent in nature and accumulate in the environment, thereby leading to serious ecological problems. So, to build our economy sustainably, a need of replacement is necessary. Biomaterials in terms of bioplastics are an anticipated option, being synthesized and catabolized by different organisms with myriad biotechnological applications. Polyhydroxyalkanoates (PHAs) are among such biodegradable bioplastics, which are considered as an effective alternative for conventional plastics due to their similar mechanical properties of plastics. A range of microbes under different nutrient and environmental conditions produce PHAs significantly with the help of enzymes. PHA synthases encoded by phaC genes are the key enzymes that polymerize PHA monomers. Four major classes of PHA synthases can be distinguished based on their primary structures, as well as the number of subunits and substrate specificity. PHAs can also be produced from renewable feedstock under, unlike the petrochemically derived plastics that are produced by fractional distillation of depleting fossil fuels. Polyhydroxybutyrate (PHB) is the simplest yet best known polyester of PHAs, as the PHB derived bioplastics are heat tolerant, thus used to make heat tolerant and clear packaging film. They have several medical applications such as drug delivery, suture, scaffold and heart valves, tissue engineering, targeted drug delivery, and agricultural fields. Genetic modification (GM) may be necessary to achieve adequate yields. The selections of suitable bacterial strains, inexpensive carbon sources, efficient fermentation, and recovery processes are also some aspects important aspects taken into consideration for the commercialization of PHA. PHA producers have been reported to reside at various ecological niches with few among them also produce some byproducts like extracellular polymeric substances, rhamnolipids and biohydrogen gas. So, the metabolic engineering thereafter promises to bring a feasible solution for the production of “green plastic” in order to preserve petroleum reserves and diminish the escalating human and animal health concerns environmental implications.