Abstract
A procedure is described for the clinical assay of hypnotics and a comparative study of two drugs in humans: Hoe 264 (Hoechst) and heptobarbital (Medomin R) is reported. This procedure measures the changes in psychological, motor and autonomic responses, as well as the electrical activity of the CNS. Several variables were used including two for the measurement of the degree of vigilance: the sustained attention and a time-interval estimation. Another three variables were used for motor responses and electrical activity of the CNS: EEG, arm muscle contraction, and reaction time. In addition the following variables were used for the study of the changes on autonomic activity: pneumogram, EKG, galvanic skin resistance, and blood pressure.
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