Abstract
Seven new dianthrone glycosides, named polygonumnolides A1–B3 (1–7), were isolated from the 70 % EtOH extract of the dried roots of Polygonum multiflorum Thunb. using column chromatography and preparative high-performance liquid chromatography. Their structures were determined by 1D and 2D NMR and mass spectroscopy. The isolated compounds were evaluated for their cytotoxic effects against KB tumor cell lines and compounds 1–4 showed moderate cytotoxicity.
Highlights
The roots of Polygonum multiflorum Thunb. are used as a traditional Chinese medicinal herb to treat many diseases
The isolated compounds were evaluated for their cytotoxic effects against KB tumor cell lines and compounds 1–4 showed moderate cytotoxicity
They are applied as remedies for preventing hair loss and premature graying, strengthening bones and muscles, and treating seminal emission and menstrual and menopausal complaints (The State Pharmacopoeia Commission 2015)
Summary
The roots of Polygonum multiflorum Thunb. are used as a traditional Chinese medicinal herb to treat many diseases.
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