Abstract

Polygonum multiflorum Thunb. and its processed products have been used in China for centuries due to their multiple beneficial effects to human body. Currently, liver injuries caused by taking P. multiflorum have been reported worldwide, but the potential toxic components and possible mechanism that caused hepatotoxicity remain unclear. It is worth noting that the processing procedure could significantly decrease the toxicity of raw P. multiflorum and the processed products of P. multiflorum are considered to be relatively safe. However, the processing mechanism is still ambiguous, and there is the lack of a scientific approach to control the quality of P. multiflorum praeparata. This study is the first review that summarizes the recently advances (from 2007 to 2017) in the chemical analysis of P. multiflorum, and provides comprehensive information on the quantitative and qualitative analysis of P. multiflorum as well as its related species. In addition, the processing mechanism and quality evaluation of processed P. multiflorum are discussed. Moreover, the toxicity of P. multiflorum is analyzed from the perspectives of exploration of the proposed toxic ingredients, metabolite identification, metabolomics studies, and exogenous contaminant determination. Furthermore, trends and perspectives for future research of this medicine are discussed.

Highlights

  • According to traditional Chinese medicine (TCM) theory, Polygonum multiflorum Thunb. (PM) is one representative drug that possesses different efficacies in its crude and processed forms (Supplementary Figure S1)

  • H. et al, 2015 chemical compositions of these three herbs, and the results demonstrated that stilbenes and anthraquinones were the main constituents, while chrysophanol, TSG, and piceid could be used as key markers in the discrimination of Rheum officinale Baill. (RO), PM, and Polygonum cuspidatum (PC), respectively

  • Various approaches were applied to monitor the transformation of principal compounds, and the results suggested that the hydrolysis reaction and Maillard reaction were involved in the steaming process of the root of PM (Liu et al, 2009, 2013; Xu et al, 2011; Yu et al, 2011; Chen et al, 2012; Wu et al, 2012; Yang et al, 2015; Zhai et al, 2016; Sun et al, 2017; Zhao et al, 2017)

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Summary

Introduction

According to traditional Chinese medicine (TCM) theory, Polygonum multiflorum Thunb. (PM) is one representative drug that possesses different efficacies in its crude and processed forms (Supplementary Figure S1). Are widely applied in the quantitative evaluation of PM (Yi et al, 2007; Han et al, 2009, 2013; Jiao and Zuo, 2009; Yan et al, 2010; Zhao et al, 2013; Liang et al, 2014; Li et al, 2016b) According to the Chinese pharmacopeia, TSG, emodin and physcion were eluted on a C18 column by the means of HPLC.

Results
Conclusion

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