Abstract
Polyglycerol coated polypropylene films were prepared in two steps by plasma bromination and grafting of polyglycerol. Films were characterized and their bioinertness against proteins and bacteria was investigated.
Highlights
Polypropylene’s inertness and high stability are interesting features for biomedicine, but its strong hydrophobicity leads to unspecific protein adsorption, which is believed to be the first conditioning step for biofilm formation, infection, and even foreign body reactions.[7]
This study presents an easy two-step protocol for the production of PG-lated polyolefin surfaces
The success of plasma bromination was checked by X-ray photoelectron spectroscopy (XPS)
Summary
In light of the rapid technological progress and demographical changes in the civilized world, biofouling has become a serious problem.[1,2,3] Polyolefins are most commonly used in biomedicine for syringes, surgical sutures, mesh implants, and blood bags, as well as for packaging purposes.[4,5,6] Polypropylene’s inertness and high stability are interesting features for biomedicine, but its strong hydrophobicity leads to unspecific protein adsorption, which is believed to be the first conditioning step for biofilm formation, infection, and even foreign body reactions.[7]. We prepared PGs with different molecular weights and amounts of amino functionality and introduced them to surfaces by a grafting-to technique.
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