Abstract
Herein, we synthesized high-performance SiO2–core quantum dot (QD)–shell nanocomposites (SiO2@PEI-QDs) using the polyethyleneimine (PEI)-mediated adsorption method. Cationic PEI was used to form a positively charged interlayer on the SiO2 core, which achieved a dense adsorption of carboxylated QDs to form a shell of QDs and maintained a good dispersibility of the nanocomposite. The SiO2@PEI-QDs showed excellent stability and high luminescence, and served as high-performance fluorescent labels for the detection of bacteria when used with the lateral flow immunoassay (LFA) technique. An SiO2@PEI-QD-based LFA strip was successfully applied to rapidly detect Salmonella typhimurium in milk samples with a low limit of 5 × 102 cells per mL.
Highlights
We synthesized high-performance SiO2–core quantum dot (QD)–shell nanocomposites (SiO2@PEI-Quantum dots (QDs)) using the polyethyleneimine (PEI)-mediated adsorption method
Our results revealed the performance and stability of SiO2@PEI-QDs and demonstrated that the proposed nanocomposites can act as advanced uorescent nanotags for QD-based lateral flow immunoassay (LFA) strips
The limit of detection (LOD) of the SiO2@PEI-QD-based strip was estimated to be 5 Â 102 cells per mL, with the LOD de ned as the 3 : 1 threshold ratio with respect to the blank signal.[24,25,26]. These results revealed that the proposed LFA strip with
Summary
We synthesized high-performance SiO2–core quantum dot (QD)–shell nanocomposites (SiO2@PEI-QDs) using the polyethyleneimine (PEI)-mediated adsorption method.
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