Abstract
Abstract Mesoporous silica nanoparticles (MSN) known as one of the best material of nanotechnology for drug delivery application with their unique properties that suit a therapeutic field. However, the major challenge for nanotechnology is premature release before reached to target cell. Thus, by incorporation of polyethylene oxide (PEO) in MSN loaded with quercetin (QT), the release profile properties can be controlled by meeting to specify pH value of cancer cell, in form of MSN/QT/PEO membrane. The samples have been characterized using FTIR, XRD, TEM, and FESEM-EDX while the adsorption of QT was carried out for 10 hours contact time which results in 80%. Based on the characterization, MSN specified a relatively higher number of pores with larger diameters while MSN/QT/PEO membrane produced the new functional group between MSN/QT with the PEO which indicate to the stronger bonded and pH-responsive at lower pH value. The image of the structure clearly differentiates the composition ratio of MSN/QT/PEO membrane in ratio of 1:0.02:4 respectively and the fabrication using a drying method for 3 days in ambient condition. The release profile had been analyzed in pH 7 and pH 4 at 37°C, and the result shows that MSN/QT released maximum rate of QT within 4 hours for pH 7 while there was negligible release of QT (less than 1%) for MSN/QT/PEO membrane meanwhile at pH 4, MSN profile release burst within early third hours in 50% while the sustained and slowly released was shown by MSN/QT/PEO membrane up to 20 hours. From this study, efficient encapsulation of drug molecules can be suggested as an alternative to the drug delivery application
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