Abstract
This single center, randomized, and controlled study aimed to compare the effectiveness and safety of polyethylene glycol electrolyte lavage (PEG-EL) solution and colonic hydrotherapy (CHT) for bowel preparation before colonoscopy. A total of 196 eligible outpatients scheduled for diagnostic colonoscopy were randomly assigned to the PEG-EL (n = 102) or CHT (n = 94) groups. Primary outcome measures included colonic cleanliness and adverse effects. Secondary outcome measures were patient satisfaction and preference, colonoscopic findings, ileocecal arrival rate, examiner satisfaction, and cecal intubation time. The results show that PEG-EL group was associated with significantly better colonic cleanliness than CHT group, fewer adverse effects, and increased examiner satisfaction. However, the CHT group had higher patient satisfaction and higher diverticulosis detection rates. Moreover, the results showed the same ileocecal arrival rate and patient preference between the two groups (P > 0.05). These findings indicate that PEG-EL is the preferred option in patients who followed the preparation instructions completely.
Highlights
China has a high incidence of lower gastrointestinal (GI) malignancies, including colon and rectal cancer [1]
Our results indicate that polyethylene glycol electrolyte lavage (PEG-EL) resulted in better colonic cleanliness, fewer adverse effects, and higher examiner satisfaction
The PEG-EL preparation had lower patient satisfaction and a lower diverticulosis detection rate compared with colonic hydrotherapy (CHT)
Summary
China has a high incidence of lower gastrointestinal (GI) malignancies, including colon and rectal cancer [1]. Colonoscopy is a minimally invasive procedure and is currently the standard method to assess colonic mucosa [2]. It is typically ordered to exclude or identify early malignant diseases in patients with warning symptoms [3]. It has been widely used in patients with intestinal disorders to diagnose or treat colon diseases, as well as for other interventions. Because colonoscopy is predominantly used as a screening tool for lower GI disorders, patient tolerability and compliance are critical for its effectiveness [3]. Attempts to improve patient acceptance of bowel preparations have primarily centered on changing the laxatives by altering electrolyte content or adding flavoring [5], or changing the bowel preparation method, such as colonic hydrotherapy [6]
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