Abstract
Prosthetic vascular graft infections of the thoracic aorta are rare but can be fatal. Our comparison of collagen- and gelatin-coated grafts showed that collagen-coated grafts were associated with increased biofilm formation and bacterial adherence in vitro and with higher rates of perioperative vascular graft infections in vivo.
Highlights
Prosthetic vascular graft infections of the thoracic aorta are rare but can be fatal
Prosthetic vascular graft infections (PVGIs) of the thoracic aorta occur in 1%–3% of patients, but lethality rates are >20% [1,2]
For our in vitro study, we compared the susceptibility of 2 thoracic vascular woven polyester grafts with different coatings—collagen and gelatin—to biofilm formation
Summary
Our comparison of collagenand gelatin-coated grafts showed that collagen-coated grafts were associated with increased biofilm formation and bacterial adherence in vitro and with higher rates of perioperative vascular graft infections in vivo. Apart from Pseudomonas aeruginosa strain 2, showed increased biofilm formation on the collagen graft compared with the gelatin graft patches (Figure, panel A). Quantitative analysis from the obtained confocal laser scanning microscopy images corroborated the initial findings because biofilm grown on collagen graft patches displayed increased total biofilm mass volume as well as maximal biofilm height (Figure, panel B). B) Total biofilm mass volume and maximal biofilm height, respectively, formed on the graft patches by the 3 clinical isolates—SA2, SE1, and EF— determined from the confocal laser scanning microscopy images with imaris software
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