Abstract
A water-soluble, core-multishell (CMS) nanocarrier based on a new hyperbranched polyester core building block was synthesized and characterized towards drug transport and degradation of the nanocarrier. The hydrophobic drug dexamethasone was encapsulated and the enzyme-mediated biodegradability was investigated by NMR spectroscopy. The new CMS nanocarrier can transport one molecule of dexamethasone and degrades within five days at a skin temperature of 32 °C to biocompatible fragments.
Highlights
In order to elaborate whether polyester-based CMS nanocarriers are suitable for hydrophobic drugs, synthesized CMS nanocarriers were tested for the encapsulation of dexamethasone
A hyperbranched polyester was synthesized in a bulk polycondensation based on adipic acid and glycerol, catalyzed by the tin catalyst DBTL
Based on 13C NMR spectroscopy, we showed that the polymerization of ε-caprolactone was initiated by both primary and secondary hydroxyl groups of mainly terminal glycerol units, which led to oligocaprolactone chains with about nine repeating units and an overall degree of functionalization of 0.67
Summary
GPC measurements in THF were performed with highly-dilute fractions eluting from a SEC system consisting of an Agilent 1100 solvent delivery system (Agilent Technologies, Santa Clara, CA, USA) with isopump, manual injector, and an Agilent 1100 differential refractometer. WinGPC Unity from PSS was used to acquire data from the seven scattering angles (detectors) and the differential refractometer. GPC in DMF data was obtained by measurements using a Shimadzu (Kyoto, Japan) liquid chromatography (LC) set up with degasser, pump, auto sampler, column oven, and differential refractometer. Three PolarSil columns (PSS Polymer Standards Service GmbH, Mainz, Germany; PolarSil 8 mm 300 mm, 100, 1000, 3000 Å with 5 μm particle size) using DMF with 0.3% LiBr and 0.6% acetic acid as the mobile phase at a flow rate of 1 mLmin were used to analyze polymer samples. LC solution software from Shimadzu was used for data acquirement and interpretation
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