Abstract
The present study was designed to evaluate the effect of polyenephosphatidylcholine (PC) on plasma lipid metabolism and lipid content in the liver of monosodium glutamate (MSG)-induced obese rats. Three groups (control group, MSG group and MSG-PC group) of male and female rats of Wistar strain were studied. MSG group and MSG-PC group were injected subcutaneously with a daily dose of MSG 4mg/g body weight for 5 days, beginning on the first day after birth. MSG-PC group was administered orally with a daily dose of PC 0.25mg/g body weight from 8th to 20th week after birth. MSG group and MSG-PC group revealed a marked increase of plasma triglyceride concentration and a slight but significant increase of total cholesterol and phospholipids concentrations in both male and female rats. There was no significant difference in plasma lipid concentrations between MSG group and MSG-PC group. Triglyceride content in the liver was significantly increased in MSG group than in control group in both male and female rats. Furthermore, triglyceride content in the liver was significantly decreased in MSG-PC group than in MSG group in male. There was no remarkable change in total cholesterol and phospholipids content in the liver among three groups. These results suggest that PC suppresses fatty liver in male MSG rats.
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