Abstract
A novel microencapsulation technology based on layer-by-layer assembly has been extensively studied and used for controlled delivery of drug microcrystal having poor aqueous solubility and low bioavailability. A non-steroidal anti-inflammatory drug ketoprofen (KF)was selected for encapsulation using biodegradable and biocompatible polyions and synergistically the fabricated system was embedded in gel matrix for topical application. Topical application of the drugs at the pathological sites offer potential advantages of delivering the drug directly to the site of action and thus producing high tissue concentrations of the drug.
Highlights
AND OBJECTIVEA novel micro-encapsulation technology based on layer-by-layer assembly has been extensively studied and used for controlled delivery of drug microcrystal having poor aqueous solubility and low bioavailability [Qiu et al 2001]
A non-steroidal antiinflammatory drug (Ketoprofen, KF) was selected for encapsulation using biodegradable and biocompatible polyions and synergistically the suspension was embedded in gel matrix for topical application
Figure shows Log% cumulative KF released Vs log time plot of KF released at pH=4.5
Summary
A novel micro-encapsulation technology based on layer-by-layer assembly has been extensively studied and used for controlled delivery of drug microcrystal having poor aqueous solubility and low bioavailability [Qiu et al 2001]. A non-steroidal antiinflammatory drug (Ketoprofen, KF) was selected for encapsulation using biodegradable and biocompatible polyions and synergistically the suspension was embedded in gel matrix for topical application. Topical application of the drugs at the pathological sites offer potential advantages of delivering the drug directly to the site of action and producing high tissue concentrations of the drug [Jain et al 2005]. Figure shows Log% cumulative KF released Vs log time plot of KF released at pH=4.5
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