Abstract
Some vinyl hydrogels containing α-amino acid residues (l-phenylalanine, l-valine) were used as polyelectrolyte platforms for the evaluation of the controlled release of two antidepressants (paroxetine and duloxetine). The closer acidity constant (pKa) values of the two drugs show a closer release profile in physiological phosphate buffered saline (PBS) buffer (pH 7.40) and for long periods of time. The great electrostatic interaction forces between the COO− group of the hydrogel and the protonated secondary amino nitrogen of the drug are the main factor improving the release kinetics; this release was found to be slower compared to that of two structurally related drugs bearing the tertiary amino nitrogen atom (citalopram and trazodone). Moreover, at the lower value of pH 4.60, paroxetine showed a flatter release profile from the hydrogel containing the l-phenylalanine residues that, after six days, is half of that shown by duloxetine. Further effects due to steric and hydrophobic interactions may contribute to the different release profile. A further stimulation with alternating magnetic fields (AMF) of low frequency (20 kHz/50 W) enhanced the release of the drug at pH 7.40 from the hydrogel containing magnetic nanoparticles. Both AMF and PBS solution at pH 7.40 were used to trigger the ‘on-demand’ pulsatile paroxetine release from the nanocomposite hydrogel.
Highlights
Hydrogels are very promising soft materials as they offer the possibility of various applications, especially in future biomedicine and in the delivery of drugs [1,2,3,4,5,6,7]
We have proposed some polyelectrolyte hydrogels based on vinyl polymers bearing α-amino acid residues [6,7,15]
Especially to strengthen the study of the controlled-release of antidepressant drugs [26], in this paper we report some results on the behavior of two molecules containing secondary amino nitrogens that are used in clinical practice: paroxetine and duloxetine [27,28]
Summary
Hydrogels are very promising soft materials as they offer the possibility of various applications, especially in future biomedicine and in the delivery of drugs [1,2,3,4,5,6,7]. They mainly consist of a macromolecular network capable of a reversible swelling-deswelling process in solvents, especially in water. Solid hydrogels in water absorb a considerable amount of liquid and this results in a swelling of the macromolecular structure that becomes soft and translucent. We have proposed some polyelectrolyte hydrogels based on vinyl polymers bearing α-amino acid residues [6,7,15]
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