Abstract
This study reports a facile approach to construct versatile zein-polydopamine-casein core-shell nanocomposites (ZPCs) for polyphenols delivery systems. The surface of zein particles was firstly modified with mussel-inspired polydopamine (PDA), and then coated with casein, forming stable colloidal particles against environmental stresses including pH, salinity, storage, re-dispersion and UV irradiation. Compared with free resveratrol (RES), the encapsulation of RES into ZPCs (RES-ZPCs) enhanced approximately 5-fold and 2.5-fold antioxidant activity for DPPH and ABTS assays, respectively. Cellular H2O2 scavenging assay of RES-ZPCs presents 100% exogenous reactive oxygen species elimination, while free RES eliminates only 63.5%. In vitro cell uptake and cytotoxicity assay show that ZPCs could be uptake and exhibits non-toxic on the cell proliferation. This concept of combining PDA and polyphenols with antioxidant activity and stability may provide new insights into designing highly active, stable polyphenols...
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