Abstract
The polycystic ovary syndrome is the most common endocrinological disorder of reproductive age women with a prevalence of 5 to 8 %. The most common diagnostic criteria used for polycystic ovary syndrome are oligo- or an-ovulation, clinical and/ or biochemical signs of hyperandrogenism and polycystic ovaries. Hyperandrogenism results in increased estrogen levels and lack of cyclic progesterone due to anovulation and persistent stimulation of the endometrium may lead to endometrial hyperplasia or adenocarcinoma development. In this mini review, we aimed to evaluate the possible relationship between polycystic ovary syndrome and endometrial cancer.
Highlights
Polycystic ovary syndrome (PCOS) is a chronic, heterogeneous and multisystem endocrinological disorder that affects 5 to 8% of reproductive age women (Barry et al, 2014)
Hyperandrogenism results in increased estrogen levels and lack of cyclic progesterone due to anovulation and persistent stimulation of the endometrium may lead to endometrial hyperplasia or adenocarcinoma development
We aimed to evaluate the possible relationship between polycystic ovary syndrome and endometrial cancer
Summary
Polycystic ovary syndrome (PCOS) is a chronic, heterogeneous and multisystem endocrinological disorder that affects 5 to 8% of reproductive age women (Barry et al, 2014). Hyperandrogenism results in increased estrogen levels and lack of cyclic progesterone due to anovulation and persistent stimulation of the endometrium may lead to endometrial hyperplasia or adenocarcinoma development. Haulo et al (2012) demonstrated that women with PCOS are three times more under risk of endometrial cancer (EC).
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