Abstract
Objective: To compare effectiveness of clomiphene alone and in combinationwith metformin in terms of conception rate in patients presenting with polycystic ovary syndrome.Study Design: Randomized clinical trail. Place and duration of study: Department Obstetricsand Gynecology Unit I, Nishtar Hospital Multan, 6 months from 12th September 2009 to 11thMarch 2010. Methodology: Primary subfertile women visiting outpatient department of NishtarHospital Multan with significant irregular menstrual cycle, oligo menorrhea and ultrasonographicfeatures of polycystic ovaries were enrolled in the study. Semen samples from male partners wereanalyzed according to the WHO criteria. Women whose partner’s semen analysis was abnormalwere excluded from study. Group ‘A’ was given clomiphene citrate alone and second group (i.e.group B) was given colmiphene citrate and metformin. All patients were followed till six cycles forregularity of menstrual cycle (determined by history) ovulation by follicular tracking onultrasonography, if patient (conceived), conception was confirmed by urine pregnancy test andgestational sac on ultrasonography pelvis. Final outcome was measured at six month.Information was entered in specifically designed proforma. Results: Frequency of PCOS was14.05%. Mean age of the patients was 31.03 ± 0.58 vs. 29.89 ± 0.53 years in group A and Brespectively. Oligomenorrhea was present in 18(50%) vs. 18 (50%) women, amenorrhea in7(19.4%) vs. 8(22.2%) patients and weight gain in 14(38.9%) vs. 15(41.7%) cases in group A andB respectively. Conception was achieved in 26(72.2%) vs. (18(50.0%) patients in group A and Brespectively. Conclusions: Metformin does not seem to help in achieving higher rates ofpregnancy when combined with CC as compared to CC alone.
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