Abstract
This present work highlights the construction of new chemosensors based on polycyclic aromatic hydrocarbon (PAH) appended organosilocane which have been structurally characterized by various spectroscopic techniques such as IR, NMR, and mass spectrometry. The prepared chemosensors were found to be proficient for the detection of Sn2+ and Cr3+ ions with UV–Visible spectroscopy and Cu2+ ion with fluorescence technique. The limit of detection for Sn2+, Cr3+ and Cu2+ ions turns out to be 5.74 ppb, 5.14 ppb and 0.55 ppm, respectively, as calculated by Benesi-Hildebrand plot and Stern Volmer graph. Moreover, biological applications like total antioxidant activity and cytotoxic studies of the prepared organosilocanes have been evaluated. Total antioxidant activity was of IC50 0.06 ± 0.01 mM and 0.2 ± 0.01 mM, for compounds 3a and 3b, respectively. Interestingly, compound 3a has a noteworthy cytotoxic activity against SAF-1 cell line with EC50 of 4.07 ± 0.32 μM. Further immobilisation of compound 3a onto the surface of magnetic silica (Fe3O4@SiO2) nanoparticles enhanced the properties of chemosensitivity for Sn2+ ion and the limit of detection lowered to 0.1 ppb. The resultant nanoparticles have been characterized by physicochemical techniques such as FT-IR, XRD, EDX, FESEM and TGA.
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