Abstract
Synthesis of a new methoxy dibenzofluorene through alkylation, cyclodehydration and aromatization in a one-pot operation is achieved for the first time. Using this hydrocarbon, a few derivatives are prepared through aromatic nitration, catalytic hydrogenation, coupling reaction with a side chain and reduction. The benzylic position of this hydrocarbon with the side chain is oxidized and reduced. Some of these derivatives have demonstrated excellent antitumor activities in vitro. This study confirms antitumor activity depends on the structures of the molecules.
Highlights
Polyaromatic compounds are prepared by numerous methods (Clar, 1964; Harvey, 1997)
Some of the methods are widely used in the synthesis of compounds containing multiple ring containing structures all of which are not aromatic
Most of the past research on polyaromatic compounds is mainly based upon two important areas: synthesis and carcinogenicity/mutagenicity
Summary
Polyaromatic compounds are prepared by numerous methods (Clar, 1964; Harvey, 1997). Some of the methods are widely used in the synthesis of compounds containing multiple ring containing structures all of which are not aromatic. Numerous polyaromatic compounds have demonstrated carcinogenic and mutagenic activities. Many clinically active anticancer drugs that are not derived from polyaromatic compounds are carcinogenic and other harmful properties. It has been shown that alteration of the structure of polyaromatic compounds can help to interact with specific organelles to evoke selective cytotoxic reactions (Palmer et al, 1992; Cherubim et al, 1993). This simple, but very crucial concept is used by many scientists and as result of these approaches many carbazoles, anthracenes, and related structures are in current clinical use (Iyengar et al, 1997; Brana et al, 2001; Martinez and Chacon-Garcia, 2005; Landis-Piwowar et al, 2006; Rescifina et al, 2006; Bandyopadhyay et al, 2012). We report our preliminary findings that uncover anticancer activities that depend on the groups present in these molecules
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