Abstract
Because within-host Mycobacterium tuberculosis diversity complicates diagnosis and treatment of tuberculosis (TB), we measured diversity prevalence and associated factors among 3,098 pulmonary TB patients in Lima, Peru. The 161 patients with polyclonal infection were more likely than the 115 with clonal or the 2,822 with simple infections to have multidrug-resistant TB.
Highlights
Because within-host Mycobacterium tuberculosis diversity complicates diagnosis and treatment of tuberculosis (TB), we measured diversity prevalence and associated factors among 3,098 pulmonary TB patients in Lima, Peru
Within-host heterogeneity of Mycobacterium tuberculosis infection is increasingly recognized as an obstacle for the accurate diagnosis [1] and effective treatment [2] of tuberculosis (TB) and may complicate the control of TB in communities [3]
Our main objectives were to estimate the prevalence of within-host M. tuberculosis heterogeneity at the time of treatment initiation in a large cohort of pulmonary TB patients in Peru and to determine if factors measurable at the baseline visit were associated with complex infections [7]
Summary
These associations were largely preserved when we repeated the analysis by using the threshold classification approach (online Technical Appendix Tables 1, 2, https://wwwnc.cdc.gov/EID/ article/23/11/17-0077-Techapp1.pdf)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
