Abstract
A comparison was made of the induction responses of two PCBs (Aroclors 1016 and 1242) on the hepatic microsomal mixed function oxidase (MFO) system in two genetically similar species, mink and European ferrets, previously shown to differ significantly in sensitivity to these same Aroclors. Feeding Aroclors for 28 days at a subtoxic level (20 ppm) resulted in weak induction of the MFO system. Aroclor 1242 was a more potent inducer than Aroclor 1016. Using a dosing regime which resulted in toxic effects in mink but not in ferrets, greater induction was noted in ferrets compared to mink. Furthermore, only 3-methyl-cholanthrene (MC)-type induction was observed. Phenobarbital (PB) inducible enzymes were either not affected or were inhibited by Aroclor treatment. The results suggest an inverse relationship between extent of MC-type induction and toxicity in these species.
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