Abstract
Bone tissue engineering has been widely studied in order to seek new strategies for the regeneration of diseased or damaged bone. Over the last year, considerable advances have been done in different aspects of bone tissue engineering. In the present study, it was attempted to use the polycaprolactone (PCL) as a biocompatible polymer for the formation of bone-like apatite. At the first, ZnO nanoparticles (NPs) were modified with folic acid (FA) and utilized as nanofillers to enhance the structural and antibacterial features of PCL. Among all NC films, PCL/ZnO-FA NC film 5 wt% was more hydrophilic. This is as a result of the uniform and homogeneous dispersion of nanofillers in the polymeric matrix, which can be affirmed by the transmission electron microscope photographs. The outcomes of bioactivity examination exhibited the well-formation of the hydroxyapatite layer on the surface of fabricated PCL/ZnO-FA NC films and the remarkable effects of the presence of ZnO-FA NPs within the PCL for improving the bioactivity properties. Also, the existence of ZnO NPs increased the resistance of these NC films against Staphylococcus aureus as a Gram-positive bacterium.
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