Polycaprolactone(PCL)/Chitosan(Cs)-Based Scaffold by Freeze Drying Technique for Tissue Engineering and Drug Delivery Application

Abstract

Tissue engineering is the promising technique to replace organ transplant in order to solve many problems regarding the shortage of organ donor and other problems related to organ or tissue transplantation such as bleeding, diseases, accidents and others. Polycaprolactone (PCL) and chitosan (Cs) are biodegradable polymers that have the properties to develop into scaffold. Both of the polymers were used in this research in order to produce scaffold by using freeze drying technique. Four samples of scaffolds were fabricated with the variety of concentration chitosan, PCL 10% (1g of PCL in 10ml glacial acetic acid), PCL/Cs 11% (1g of PCL and 0.1g of chitosan in 10ml glacial acetic acid), PCL/Cs 12% (1g of PCL and 0.2g of chitosan in 10ml glacial acetic acid) and also PCL/Cs 13% (1g of PCL and 0.3g of chitosan in 10ml glacial acetic acid). The produced scaffolds had good properties from both polymers such as faster degradation rate, hydrophilic, porous and others.