Abstract
Magnesium (Mg) is widely used in different tissue engineering applications such as bone fracture fixations and cardiovascular stent applications. However, it exhibits high degradation properties in the physiological medium and hence loses its mechanical properties. Herein, AZ31 Mg alloy was spin-coated with polycaprolactone (PCL) polymer blended with Schiff base derived from amino acid as a corrosion inhibitor. Coated samples were characterized using field emission electron microscopy (FESEM) and Fourier-transform infrared spectroscopy (FTIR) analysis. Additionally, corrosion behavior was evaluated using electrochemical potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) techniques. Moreover, the bioactivity of the studied samples was confirmed in vitro with MC3T3-E1 osteoblasts cells. Results show that coated samples with corrosion inhibition efficiency of blended PCL and L-isoleucine Schiff (PCL-SI) reached 66% compared to that of pure PCL 39%. This suggests that the introduced materials were superior to control biodegradability and biocompatibility of the bare alloy in bone tissue engineering application.
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