Polycaprolactone, polylactic acid, and nanohydroxyapatite scaffolds obtained by electrospinning and 3D printing for tissue engineering

Abstract

There is a deficit for bone tissue natural grafts that seek to be covered with synthetic substitutes. Scaffolds generated with 3D printing and electrospinning allow adequate mechanical properties maintaining a structure appropriate for cell growth. Here, a scaffold made up of three-dimensional (3D) printed PLA frameworks added with PCL/PLA/nHA nanofibers was manufactured. The framework showed mechanical properties similar to other reported bone substitutes, while the nanofibers showed diameters between 200 and 850 nm. Scaffolds were suitable for cell adhesion and proliferation when evaluated with fibroblasts, showing cell proliferation into the nanofiber network, a fundamental aspect in tissue engineering.