Abstract
A single oral dose of 200 mg/kg polybrominated biphenyl (PBB) maximally increased the serosal transfer of iron about 50% in duodenal gut sacs prepared from treated rats. Smaller doses caused inconstant changes in iron transport. The effect, which was maximal at 2 days after treatment, returned to normal at 4 days, and then was increased 16 and 24% at 7 and 18 days, respectively. Iron absorption in vivo increased 29% in rats given 0.1 mg orally five times weekly for 5 weeks. The stimulation of iron absorption was accompanied by an 18% increase in serum iron. The activities of the intestinal and hepatic aryl hydrocarbon hydroxylase was increased in a manner that did not directly correlate with the effects on iron transport, suggesting that the control mechanism for the different biochemical effects are not directly related.
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