Abstract
Polyarteritis nodosa (PAN), first described by Kussmaul and Maier [1], is a well-known form of necrotizing angiitis whose main manifestations are: weight loss, fever, asthenia, peripheral neuropathy, renal involvement, musculoskeletal and cutaneous manifestations, hypertension, gastrointestinal (GI) tract involvement and cardiac failure. Churg-Strauss syndrome (CSS) [2] is a disorder characterized by hypereosino-philia and systemic necrotizing vasculitis similar to that of PAN and occurring in individuals with asthma and al.lergic rhinitis. The PAN group of vasculitides is heterogeneous and comprises classic PAN (c-PAN), microscopic polyangiitis (MPA), CSS and overlap syndrome. Considering the etiologies of PAN, primary and secondary vasculitides can al.so be distinguished, since PAN can be the consequence of hepatitis B virus (HBV) infection and sometimes of other etiological agents. Only c-PAN is addressed in this chapter; MPA and CSS are treated in detail elsewhere.
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