Abstract
Here we report electrospinning of Poly(dimethylsiloxane-b-vinyl pyrrolidone) (PDMS-b-PVP) based fibrous scaffold materials. The morphology, thermal properties, surface composition, hydrophilicity and fibers formation with different PDMS and PVP chain lengths were determined by using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), X-ray photoelectron microscopy (XPS) and X-ray diffraction (RXD) water vapor uptake and water contact angle (WCA). The electrospinning parameters were controlled as well as fiber deposition area. The influence of polymer solution concentration on the morphology of electrospun fibers was also investigated. We checked out the applicability of the electrospun fibers for tissue engineering by the investigation of their capability to support fibroblast cell adhesion, cell growth and proliferation.
Highlights
Electrospinning is a unique technique that can produce non-woven fibrous materials with fiber diameters ranging from nanometers scale to micrometers scale
The surfaces of the fiber mats are seen to consist of carbon, oxygen and silicon from PDMS and carbon, oxygen and nitrogen coming from PVP
The C 1s core-level spectrum of the PDMS-b-PVP fibers shown on Figure 7 can be deconvoluted by curve fitting into three components: the sp3-hybridized carbon peak with a binding energy (BE) at 284.6 eV corresponding to the two side
Summary
Electrospinning is a unique technique that can produce non-woven fibrous materials with fiber diameters ranging from nanometers scale to micrometers scale. The important advantages of this technique are the production of very thin fibers with large surface areas, excellent mechanical properties, facile modification and ease of process [1]. Block copolymer scaffolds can be electrospun in fibers, combining the unique physicochemical and biological properties and the ability to control the fibers structure during electrospinning process by the control of different parameters [2], which offers opportunity for new biomaterials fabrication with unusual properties. The polymer material selection plays a key role in the fabrication of scaffold with desired properties. They can be achieved by combination of homo polymers advantages in blended solutions (natural and/or synthetic polymers), copoly-. The electrospinning of block copolymers is promising for applications involving surface chemistry, drug delivery, tissue engineering and multifunctional textiles, and is of scientific interest
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