Abstract
The uneven distribution of polyamines in the different cell types of mammalian retina documents the functional accumulation of spermine in photoreceptor cells. Polyamine interconversion in non-growing organs is responsible for the maintenance of putrescine levels and polyamine turnover. Administration of methylglioxal bis[guanylhydrazone] was chosen because this compound is known to inhibit S-adenosylmethionine decarboxylase and to induce spermidine/spermine N 1-acetyltransferase. The combined treatment with both, an inhibitor of S-adenosylmethionine decarboxylase and of polyamine oxidase caused a significant accumulation of N 1-acetylspermine, greater than that of N 1-acetylspermidine. These results are in agreement with the observations that polyamine reutilization in the adult nervous tissues is a major source of spermidine and putrescine.
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