Abstract
Interference with the transcription of specific genes in vivo can be achieved with artificial, low molecular weight pyrrole-imidazole polyamides, as shown by recent studies by Gottesfeld, Dervan et al. This is possible because these ligands are capable of binding with high affinity and specificity to predetermined DNA sequences in the minor groove of double-stranded DNA (see schematic representation on the right; gray: pyrrole, black: imidazole units).
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