Abstract
A polyacrylonitrile thin film composite membrane has been used as the outer covering barrier in an amperometric glucose oxidase enzyme electrode. The composite membrane was formed via the cathodic electropolymerization of acrylonitrile at gold sputter coated highly porous host alumina membranes. Membranes of this type served as diffusion limiting barriers to the enzyme substrates. Anionic interferents such as ascorbate were also excluded via the use of the membrane by means of a charge exclusion mechanism. Oxygen and glucose permeability coefficients were determined using diffusion chamber apparatus. On exposure to blood, a 25% signal drift was observed over a period of 1 h. Blood glucose determinations were performed following this initial exposure to blood since after this time the performance of the electrode remained almost stable. Glucose determinations within whole blood patient samples performed using the enzyme electrode sensor developed here compared favorably to standard hospital analyses with a correlation coefficient of r2=0.94.
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