Polyacrylamide mammary syndrome — specificity of the histological pattern of the focus before and after air-plasma treatment

Abstract

BACKGROUND: At the end of the twentieth century, mammary gland contour correction using polyacrylamide gel (PAAG) became widely popular. The surgical approach must be improved because of the negative consequences associated with this technique.
 AIM: This study aimed to evaluate the possibilities of air-plasma technology in the treatment of long-term septic manifestations of polyacrylamide mammary syndrome as well as the prevention of its recurrence based on the analysis of histological examination findings.
 MATERIALS AND METHODS: Biopsy samples of eight women aged 38 to 59 years, who had undergone gel augmentation of the mammary glands six to 20 years ago, were studied. The complex treatment included air-plasma flow in cutting coagulation modes and nitric oxide therapy. A morphological study of the focus was performed before and after exposure to the plasma flow.
 RESULTS: Before treatment, chronic granulomatous inflammation and helioma were revealed in six cases; and acute phlegmonous-necrotic soft tissue inflammation in two cases. On the fifth day after combined necrectomy, single loci of the gel were visualized, the majority of which was vaporized. Chronic inflammation was less pronounced than the original histograms. During the sanitation with nitric oxide, the early appearance of foci of fibroblastic proliferation and marginal epithelialization was registered.
 CONCLUSIONS: Exposure to the air-plasma flow contributes to effective sanitation of purulent focus and gel total elimination Nitric oxide therapy (NO-therapy) accelerates the development of granulation tissue.