Abstract
Purpose: Intra-articular (IA) injection of polyacrylamide hydrogel (PAAG) has been suggested as a possible treatment for symptomatic osteoarthritis (OA). Previously IA PAAG has been investigated using 2 injections of 3 ml separated by a month. The primary objective of this study was to evaluate the efficacy and safety of a single injection of 6 ml intra-articular PAAG on knee symptoms in participants with moderate to severe knee OA.
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