Polyacrylamide grafted Eucalyptus camaldulensis (EC-g-PAM) gum as an efficient binding agent in drug formulations

Abstract

The use of plant based gums in pharmaceutical sphere is desirable binding agents during pharmaceutical formulations. In this research, Eucalyptus camaldulensis gum is modified by microwave irradiation in order to estimate its binding characteristics for the fabrication of varied pharmaceutical formulations. Gum is analyzed in three forms; native, purified and grafted EC-g-PAM. The distinctive chemical assays for the characterization of carbohydrates indicated the existence of reducing sugars in all three types native, purified and grafted EC (EC-g-PAM) gum extracts. The relatively high phenolic contents i.e. 0.159 μg ml−1 GAE of grafted EC extract indicate considerable antioxidant potential worthy of further investigations. In case of antimicrobial assay, grafted gum proved to be highly effective and produced a wider ring of no bacterial growth with for E. coli while showed comparatively lesser change in the surrounding S. aureus concentration. Owing to its non-toxicity, it is incorporated into the paracetamol and it revealed excessive controlled drug-release profiles. Grafted gum possessed significantly controlled drug release profile, thus, the drug formulations based on the proposed gum, could be more beneficial site-specific oral drug carrier system.