Abstract
Polymer capped metal nanoparticles have been used for numerous biomedical and analytical applications. In present study, highly stable gold nanoparticles (AuNPs) capped with polypropylene glycol (PPG) were synthesized using chemical reduction method. The characterization of PPG-AuNPs was accomplished by atomic force microscopy (AFM), zetasizer, fourier transform infrared spectroscopy (FT-IR) and UV–vis spectroscopy. Furthermore, PPG-AuNPs were utilized as colorimetric probe for third generation cephalosporin antibiotic, ceftriaxone (CEF). PPG-AuNPs permitted efficient, selective, quantitative and rapid recognition in concentration range of 0.1–100μM in presence of numerous other drugs and salts. PPG-AuNPs have great potential for quantitative recognition of ceftriaxone in biological and environmental samples. Moreover, the developed sensor has capacity to be applied as quality control of pharmaceutical formulations containing ceftriaxone. The PPG-AuNPs based sensor permits quantitative and fast recognition of ceftriaxone away from a sophisticated laboratory setup.
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