Abstract
The aim of this study was to investigate an antimicrobial and degradable composite material consisting of melt-blown poly(lactic acid) nonwoven fabrics, alginate, and zinc. This paper describes the method of preparation and the characterization of the physicochemical and antimicrobial properties of the new fibrous composite material. The procedure consists of fabrication of nonwoven fabric and two steps of dip-coating modification: (1) impregnation of nonwoven samples in the solution of alginic sodium salt and (2) immersion in a solution of zinc (II) chloride. The characterization and analysis of new material included scanning electron microscopy (SEM), specific surface area (SSA), and total/average pore volume (BET). The polylactide/alginate/Zn fibrous composite were subjected to microbial activity tests against colonies of Gram-positive (Staphylococcus aureus), Gram-negative (Escherichia coli) bacterial strains, and the following fungal strains: Aspergillus niger van Tieghem and Chaetomium globosum. These results lay a technical foundation for the development and potential application of new composite as an antibacterial/antifungal material in biomedical areas.
Highlights
Wound healing is a dynamic and complex process affected by several factors, which needs an appropriate surrounding to achieve accelerated healing [1]
Samples of PLA nonwoven fabric were impregnated in a homogeneously dispersed polysaccharide solution (0.5%) for 1 min (sample: PLA-AlgNa(+) ), each sample was immediately transferred into two different aqueous solutions of zinc (II) chloride and re-immersed for 1 min (sample PLA-Alg-Zn(2+) -1 re-immersed in 5% ZnCl2 solution and sample PLA-Alg-Zn(2+) -2 re-immersed in 10% ZnCl2 solution)
The results demonstrated that PLA and PLA-ALG Zn(2+)
Summary
Wound healing is a dynamic and complex process (phases: hemostasis, inflammation, proliferation, and maturation) affected by several factors, which needs an appropriate surrounding to achieve accelerated healing [1]. Modern wound healing dressing should exhibit non-toxic and non-allergenic properties, be capable of maintaining high humidity at the wound site while removing excess exudate, antibacterial characteristics or at least impermeability to bacteria, enable gaseous exchange, and be cost effective [2–5]. These requirements are partly fulfilled by the physico-chemical properties of PLA (biocompatibility, biodegradability, mechanical strength) [6–15] and to a much larger extent by PLA-composites equipped with a wide spectrum of antimicrobial agents, including inorganic microbials [16,17].
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